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郑子龙博士学术报告(6月28日15:00,化西一楼贵宾厅)
来源: 作者: 更新时间:2019-06-25

报告人:郑子龙博士

报告题目:Routes to N-glycinamideoxazolidinone derivatives: The reaction of 4- trityloxymethyl-3-oxa-1-azabicyclo[3.1.0]hexan-2-one with active halides

报告时间:2019628日(周五)下午15:00

报告地点:化西一楼贵宾厅


报告摘要:

N-Glycinamideoxazolidinones are key intermediates for the synthesis of a new class of peptidomimetics. We present herein the synthesis of a series of 3,4,5-trisubstituted oxazolidinones with a glycine residue at N-3 of the oxazolidinone ring. Substituents at C-4 and C-5 contain substitution capabilities which are amenable for the introduction of additional peptide chains. The synthesis of the key N-Glycinamideoxazolidinone is made possible through two reactions; a tandem aziridine ring opening/oxazolidinone alkylation and, subsequently, a fused-lactone ring opening by an amine which leads to the N-Glycinamideoxazolidinones.


郑子龙简介:

2010-2016 美国俄亥俄大学博士,2009-2010 美国德州农工大学考莫斯分校硕士,1999-2003山东大学,本科。郑子龙博士曾先后在中国科学院上海有机化学研究所麻生明院士课题组,美国普渡大学诺贝尔奖获得者Negishi教授课题组,美国Promiliad Biopharma Incorporated,巴塞利亚药业(中国)有限公司从事有机化学研究。郑子龙博士曾经在J. Am. Chem. Soc., Angew. Chem. Int. Ed.等杂志发表文章8篇,引用约500多次。郑子龙博士关注教育事业,在留美期间曾资助多名化学,物理,数学专业的本科生赴美攻读博士学位。


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